Will Lee: People is fundamentally and foremost a storytelling platform. My persistent focus is making sure the quality of the storytelling is at the highest level. Folio: talked with Lee about his approach, what’s working and why. Lee: We’re in sort of a post-pageview world. There are a lot of different metrics we look at and it depends on what our goals are. Some stories we’re very invested in making sure it’s engaging, so how long do people spend on it and how many share it. Other stories, like on an awards night we want to see as many people come to the site and consume as much content as they possibly can. So it depends. But pageviews is one metric, visits is another, and engagement in 2016 and 2017 is going to be essential. Lee: Like everything else in the world, decisions need to be driven by logic, not magic. There’s a level at which we can be much more crisp in our decisionmaking. We’ve got a great editorial team with great instincts and they do really good work, but it’s a very different world when you can give somebody much deeper and more persistent focus, they’re doing things that really drive audience. And the more we learn about the stories we’re telling, the more we’re able to make them better and sharper and to really give the audience more of what they want. That’s the ultimate purpose and outcome we’re trying to see by using data to drive content. Folio: What are your primary goals now for People.com? Part of the approach here is what we like to call thin slicing, meaning that when we know that there’s a great story and the audience is responding to it, instead of doing just one story and hoping it goes well, we’ll do 15 or 20. But we create as many entry points for reader as possible, because everybody has a slightly different point of entry on a given topic. Folio: How does your approach differ? Lee: There was very little challenge in getting writers and editors to get the new data-driven approach to stories. Our journalists are fiercely competitive and they want to win—and they do. And our brand’s Editorial Director, Jess Cagle (my boss), has been instrumental in driving new initiatives. As far as changing metabolism goes—our spirit animal is the hare, because, as our board member David Bell likes to say—and this is the G-rated version—the tortoise only beats the hare in fairytales. When we look very carefully at content that performs, it’s actually pretty granular. We have to look at what are the elements and do controlled experiments and literally change very small coefficients within the story to really understand: is it the headline, is it the subject, is it time of day? All of those factors go into how we program. Folio: How is that translating for People.com? Folio: How would you describe your editorial/content mission at People.com? Folio: How has staff been motivated to change to a data-driven content culture? Lee: For me, it’s fundamentally about new storytelling for new audiences and driving new revenue streams. It’s important for us to figure out how to create great content for brands. We’re great storytellers, and brands should want to align with us because we can do that better than any of our competition. From a new audiences perspective, we need to be ubiquitous. Whether it’s with mobile, whether its Snapchat Discover, and the seven other apps and destinations that we’ve never heard of but are being created somewhere right now, we’ll be there. Everyone understands the urgency of what we’re doing, and that we have to be nimble, we have to be agile, and we have to be fast, fast, fast. That’s why our weekly digital win award for is now called the Most Valuable Bunny. What’s been especially helpful here at Time Inc. is that every executive has supported the culture change, and has encouraged us to push the teams to go beyond what they’ve been doing before. Again, we’re a competitive lot, and we understand how crucial it is for us to win. The Internet is full of click bait. What differentiates us is that we are the originator of these stories. We tell the best stories in the most creative way and we have the best journalists on the planet. Folio: What’s your approach to using data? That’s what drives our decisionmaking the next day or next week. When there’s a breaking story, and we’re watching our real-time data, we do adjust on the fly, so it’s obviously looking at things like headlines and the photos we use and all of that gets adjusted on the fly. Lee: A lot of news organizations and publications can be very binary about how they program based on data. They’ll say like this did really well so let’s do more of it tomorrow. But I don’t think that’s really the case. There are a lot of extrinsic factors that can determine why a story does well. So it’s not so much we’ll do more of it just because it performed well. It’s far more nuanced than that. When we look at things that have been successful or performed well, we want to understand exactly why. Will Lee has put his stamp on People.com. Since the TMZ and Hollywood Reporter veteran became digital editorial director for People.com and EW.com in October 2014, traffic has exploded. The People Digital Group hit a record 51 million unique visitors in January, and the People/Entertainment Weekly Network was the leader in the entertainment news category for the 10th consecutive month. We don’t just do things to drive audience. People is fundamentally and foremost a storytelling platform. The more we learn about the stories we’re telling the more we’re able to make them better and sharper and to really give the audience more of what they want. That’s the ultimate purpose and outcome we’re trying to see by using data to drive content. We have to be early adopters and execute well on different platforms. From a new storytelling standpoint it’s important for us to figure out what the atomic unit of content is for audiences today. It’s probably not simply an article with a headline and 300 words of text. It could be video, it could be a Snap. There are many, many ways to tell stories and relay news. Whether its Amazon Echo, or the front of your refrigerator or the bathroom mirror those are all places you’re going to consume content, we have to figure out how to tell our stories on all of those surfaces. I’d like to say I’m able to look into the future, but unfortunately the future is upon us.
Digital Media Tech Industry Internet Services Post a comment NBC Universal CEO Steve Burke is also executive vice president of the Comcast division. Alexander Tamargo/Telemundo/NBCU Photo Bank via Getty Images NBC Universal may launch its own on-demand video platform next year.CEO Steve Burke, who heads the Comcast division, unveiled in a holiday greeting to employees that a streaming service may come soon, according to Bloomberg’s report on Tuesday. The message was reportedly written in the rhyming style of Dr. Seuss.”While you all go off to relax, swim or ski,” Burke reportedly wrote. “Maybe, just maybe, next year we will announce our plan for OTT.”OTT means “over-the-top” services that stream videos online, like Netflix. NBC Universal didn’t immediately respond to a request for comment. Traditional cable TV giants are racing to compete with Netflix, which in October unveiled that the company had accumulated over 137.1 million subscribers worldwide. US subscribers nearly doubled what Netflix had predicted.Disney plans to launch its own streaming service, called Disney+, in 2019, which would become the new home for films from Walt Disney Studios, Pixar and other studios under its umbrella.AT&T is also brewing its own on-demand streaming service. The carrier’s WarnerMedia in November said the company planned to offer a three-tier video subscription service in the fourth quarter of next year. CNET’s Holiday Gift Guide: The place to find the best tech gifts for 2018.Best Netflix series: There’s no shortage of original Netflix series to binge. Tags NBC 0 Share your voice
A second suspected US drone strike on Tuesday killed six people on the mountainous Pakistan-Afghanistan border, after a strike a day earlier that killed 20, government and militant sources said.The attacks came days after a Canadian-American couple held hostage by the Taliban were freed from the area in Pakistan’s northwest, striking a rare positive note in the country’s often-fraught relations with the United States.On Friday, US drones were seen hovering near where American Caitlan Coleman, her Canadian husband, Joshua Boyle, and their three children, all born in captivity, were freed, after having been kidnapped by the Haqqani network while backpacking in Afghanistan in 2012.“Four unmanned drones fired six missiles in Monday’s attack and two more were dropped on Tuesday,” said Baseer Khan Wazir, the top administrative official in the Kurram Agency, part of Pakistan’s restive Federally Administered Tribal Areas.The drones fired missiles on Taliban hideouts, killing at least 26 people over two days, he added, with both attacks taking place on the Afghan side within 300 metres (328 yards) of the frontier.“Twenty people were killed yesterday, mostly from the Afghan Taliban, and six more were killed in today’s attack,” Wazir told Reuters.Taliban sources said 18 members of the Pakistan-based Haqqani militants, allied to the Taliban, were killed in Monday’s strike and six more on Tuesday.“There were some mud-built houses which were being used by the mujahideen (Afghan Taliban fighters),” said a member of the Afghan Taliban, who asked not to be identified.“The drones fired six missiles on Monday and two more today, targeting two, three different compounds.”No prominent militants were in the area, he said. Another Taliban source said two commanders were killed in the attack, however.Witnesses said they heard the drones and saw plumes of smoke before seeing 20 makeshift coffins moved out of the area.“There are always drones hovering over this border area, but this was the first time four drones were noticed at the same time,” said Kurram resident Gulab Sher.
Popular music has gradually become angrier and sadder over time, and the expression of joy has declined, a study has found. While music fans preferred joyful songs during the 1950s, modern music consumers are more interested in songs that express sadness or anger, researchers said. Data scientists at Lawrence Technological University in the US used quantitative analytics to study the change in lyrics of popular music over seven decades, from the 1950s to 2016. Also Read – Add new books to your shelf”The change in lyrics sentiments does not necessarily reflect what the musicians and songwriters wanted to express, but is more related to what music consumers wanted to listen to in each year,” said Lior Shamir, from Lawrence Technological University. Research analysed the lyrics of over 6,000 songs of the ‘Billboard Hot 100’ in each year. In the past the songs were ranked mainly by record sales, radio broadcasting, and jukebox plays, but in the more recent years it is based on several other popularity indicators such as streaming and social media to reflect the changes in music consumption. Also Read – Over 2 hours screen time daily will make your kids impulsiveThe tones expressed in each song were analysed by applying automatic quantitative sentiment analysis. Automatic sentiment analysis associates each word or phrase in the song with a set of tones that they express. The combination of the tones expressed by all words and phrases of the lyrics determines the sentiment of that song. The sentiments of all Billboard Hot 100 songs in each year are averaged, and the average of each year allows to measure whether the expression of that sentiment increased, decreased, or remained constant. The analysis showed that the expression of anger in popular music lyrics has increased gradually over time. Songs released during the mid 1950s were the least angry, and the anger expressed in lyrics has increased gradually until peaking in 2015. The analysis also revealed some variations. Songs released in the three years of 1982-1984 were less angry compared to any other period, except for the 1950s. In the mid 1990s, songs became angrier, and the increase in anger was sharper during that time in comparison to previous years. The expression of sadness, disgust and fear also increased over time, although the increase was milder compared to the increase in the expression of anger. Disgust increased gradually, but was lower in the early 1980s and higher in the mid and late 1990s. Popular music lyrics expressed more fear during the mid 1980s, and the fear decreased sharply in 1988. Another sharp increase in fear was observed in 1998 and 1999, with a sharp decrease in 2000. The study also showed that joy was a dominant tone in popular music lyrics during the late 1950s, but it decreased over time and became much milder in the recent years.
Staffordshire Moorlands Stafford Borough, Rugeley, Uttoxeter M6, A500 and A50 Bridge to close for seven months Stoke-on-Trent South Cheshire Newcastle Borough Full list of roadworks South Cheshire: A – B A500: Lane closure at Mermeoor Roundabout/Shavington bypass from October 25 until October 26 A500: Lane closure at Crewe Green Link Roundabout from October 25 until October 26 A500: Lane closure at Shavington Bypass Roundabout in Shavingtom Cum Gresty from October 25 until October 26 A500: Lane closure at Cheerbrook roundabout from October 25 until October 26 Alsager: Multi-way signals on B5078 Chells Hill in Betchon at the junction of Sandbach Road from October 22 until November 9 Alsager: Carriageway incursion on Close Lane from October 10 until October 29 Alsager: Multi-way traffic signals on Hellyar Brook Road at the junction with Dunnocksfold Road from October 17 until October 23 Alsager: Carriageway incursion on Linley Road on October 22 Alsager: Stop/go boards on Pikemere Road on October 22 Betchton: Two way traffic signals on A50 Newcastle Road over Lynnhouse Bridge Bosley: Two way traffic lights on Tunstall Road near Bosley Wood Treatment until February 2019. Read MoreGunman threatens Subway staff in armed robbery Congleton: Congleton: Carriageway incursion on Longdown Road from October 17 until October 23 Congleton: Roadworks and road closure on Fol Hollow from A34 Newcastle Road until Bankyfields Crescent from October 16 until October 24 Congleton: Two way traffic signals on A527 Park Lane from October 19 until October 25 Congleton: Carriageway incursion on Walfield Avenue from October 15 until October 30 Crewe: Crewe: Multi-way traffic signals at junction of Bleasdale Road and Rydal Mount from October 18 until November 1 Crewe: Carriageway incursion on Broughton Road from September 24 until November 2 Crewe: Ongoing roadworks at Crewe Green Roundabout until December 1 Crewe: Carriageway incursion on A534 Crewe Road from October 18 until October 22 (outside number 332) Crewe: Two way traffic signals on Dunwoody Way from Dunwoody Way Roundabout from October 22 until November 16 Crewe: Road closures and roadworks on Franklyn Avenue from October 22 until October 24 Crewe: Give and take traffic control on Hungerford Road near number 339A from October 25 until October 26 Crewe: Carriageway incursions and road closures on Mablins Lane near Sunnyside Place until November 4 Crewe: Roadworks on Maw Green Road until October 31 Crewe: Multi-way traffic signals at junction Middlewich Road/Wistaston Green Road from July 23 until October 25. Crewe: Give and take traffic control on Middlewich Street from October 19 until October 22 Crewe: Stop/go boards on A5019 Mill Street from October 26 until October 29 Crewe: Stop/go boards on Moreton Road from October 17 until October 23 Crewe: Give and take traffic control on Nelson Street from October 22 until October 24 Crewe: Multi-way traffic signals on Parkers Road near the Eight Farmers from October 15 until October 29 Crewe: Roadworks and road closure on Ruskin Road on October 22. Crewe: Roadworks and traffic signals at junction of Somerville Street/Lunt Avenue and Claremont Road until October 29 Crewe: Sydney Road closed from midnight on Saturday October 26 until 7am on Sunday October 27 Crewe: Roadworks and road closure on A532 West Street on October 22 Crewe: Two way signals on West Street outside number 268 from October 24 until October 30 Crewe: Carriagewway on West Street near junction of Frank Webb Avenue on October 27 Crewe: Roadworks and road closure on Wheatley Road from October 22 until October 23 Crewe: Roadworks and road closure around the railway bridge on Wistaston Road from September 20 until November 11 Read MoreAir ambulance called as A529 closed due to serious accident H – R Hough: Two way traffic signals on Cobbs Lane from October 26 until October 30 Hough: Two way traffic signals on Newcastle Road from October 23 until October 26 Minshull Vernon : Two way traffic signals on Eardswick Lane near High Farm from October 24 until October 26 Moreton: Two way traffic signals near junction with Newcastle Road from October 22 until October 24 Nantwich: Multi-way traffic lights at junction of Arnhold Street and Cowfields from October 23 until October 25. Nantwich: Stop/go boards on Blankney Avenue on October 22 Nantwich: Stop/go boards on Edmund Wright Way from September 28 until November 2 Nantwich: Roadworks overnight at level crossing on B5074 London Road from October 25 until October 26 Nantwich: Carriageway incursions on A530 Peter Destapleigh Way from October 1 until October 26 Nantwich: Carriageway incursion on Pillory Street on October 28 Nantwich: Two way signals on Wybunbury Lane at the side of the Cedars from October 24 until October 26 Odd Rode: Multi-way traffic signals at junction of Grays Close and The Bank from October 15 until October 26 Rode Heath: Stop/go boards on Heath Avenue on October 22 Read MorePolice investigate as pupil excluded after shocking video of school fight emerges on social media S Sandbach: Carriageway incursion on Bradwall Road near junction with Chapel Street from October 24 until October 26 Sandbach: Plant Lane closed at Canal Bridge on October 24 and October 26 Sandbach: Multi-way traffic lights on A534 Congleton Road at the junction with Holmes Chapel Road on October 28 Sandbach: Carriageway incursion on High Street near numbers 40-42 from October 21 until October 23. Sandbach: Two way signals on A533 Middlewich Road near Turnpike Court and Co-op from October 25 until October 26 Sandbach: Carriageway incursion on B5079 Station Road near Moss Lane from October 22 until November 5 Scholar Green: Roadworks and road closures at the canal birdge on Little Moss Lane from September 26 until October 24 Scholar Green: Road closure on Nursery Lane on October 27 Smallwood: Road closure on Church Lane on October 26 Somerford : Carriageway incursion on A54 Holmes Chapel Road at Braken Barns from October 22 until October 26 Stapeley: Stop/go boards on A529 Broad Lane near Primary School on October 24 Stapeley: Two way traffic signals on First Dig Lane from October 19 until October 25 Read MoreBritain’s strongest man Eddie Hall has now taken up boxing – and he’s vowed to KNOCK OUT this rival W Wildboarclough: A54 Buxton Road closed in both directions until November 4. Willaston: Carriageway incursion on Cheerbrook Road from October 22 until October 24 Willaston: Multi-way traffic signals at junction of Wybunbury Road and Cheerbrook Road from October 26 until October 30 Willaston: Roadworks and lane closure at Peacock Roundabout (Crewe Road/Nantwich Bypass) until October 7 Willaston: Roadworks and road closure at level crossing on Wistaston Road on October 28 Willaston: Carriageway incursion on Wistaston Road near junction with Moorfields and Gladstone Street from October 24 until October 26 Wybunbury/Shavington: Roadworks and road closure on Dig Lane from October 27 until October 29 Want to keep up to date with the latest traffic and travel news?Each day Stoke-on-Trent Live journalists bring you the latest news on the roads and railways across Stoke-on-Trent, North Staffordshire, South Cheshire and further afield to help keep you on the move. For the very latest updates on roads including the M6, A500, A50 and more, visit our dedicated traffic and travel news channel here. We also run a live news feed each weekday, which you can access on our website’s homepage from 7am to 9pm from Monday to Friday. And for more as-we-get-it updates on the roads across the region and beyond, join The Sentinel’s traffic and travel Facebook group here. Want to tell us about something going on where you live? Let us know – Tweet us @SOTLive or message us on our Facebook page . And if you have pictures to share, tag us on Instagram at StokeonTrentLive . Get the biggest Daily stories by emailSubscribeSee our privacy noticeThank you for subscribingSee our privacy noticeCould not subscribe, try again laterInvalid Email Drivers are being warned to expect traffic and travel delays due to roadworks across South Cheshire this coming week. Motorists hitting the roads of the area on Monday morning can expect a raft of delays and road closures waiting for them. The following roadworks are taking place in the area between Monday October 22 and Sunday October 28. This list contains only the roadworks considered to be most likely to cause delays on key routes as well as those involving road closures and temporary traffic lights. It is not exhaustive and does not feature some minor or emergency repairs that come up after publication. Other roadworks may finish or start before schedule or be cancelled altogether. If you only want information about roadworks in a different area of North Staffordshire and South Cheshire, visit the links below, otherwise scroll down for the roadworks most likely to disrupt your journey in South Cheshire in the coming week All information from Highways England, local authorities and utility companies. Read MoreRoadworks from October 22 until October 28
The Google Chrome team announced new updates and changes to the Chrome DevTools in Chrome 71, today. The latest update explores features such as hovering over a Live Expression to highlight the DOM node, storing DOM nodes as global variables, Initiator and priority information in HAR imports and exports, and Picture-in-Picture breakpoints among others. Let’s discuss these features in the latest update to DevTools in Chrome 71. Hovering over Live Expression to highlight DOM node Now when an Expression evaluates to a DOM node, hovering over the Live Expression will result in highlighted DOM node in the viewport. Storing DOM nodes as global variables You can now store DOM nodes as a global variable. All you need to do is run an expression in the console that evaluates to a node. Then right-click the result and select Store as the global variable. Alternatively, you can also right-click the node in the DOM Tree and then select Store as a global variable. Initiator and priority information available in HAR imports and exports DevTools now comprises initiator and priority information in the HAR file on exporting a HAR file. Once done importing the HAR files back into DevTools, the Initiator and Priority columns gets populated. The _initiator field offers information behind the cause of the requested resource. The _priority field states the priority level that the browser assigned to the resource. Accessing Command Menu from the Main Menu Command Menu provides a fast way to access DevTools panels, tabs, and features. Now, you can open the Command Menu directly from the Main Menu. Click the main button on the main menu and select Run command. “Add to homescreen” now called “Trigger beforeinstallprompt” There’s an Add to homescreen button on the Manifest tab which is renamed to Trigger beforeinstallprompt as it is more semantically accurate. For more information, check out the official update notes. Read Next Chrome 69 privacy issues: automatic sign-ins and retained cookies; Chrome 70 to correct these Google announces Chrome 67 packed with powerful APIs, password-free logins, PWA support, and more Google Chrome’s 10th birthday brings in a new Chrome 69
Sesame Workshop, the non-profit educational organisation behind Sesame Street, has launched Sesame Go, a new subscription VoD service that offers access to episodes of the famous kids TV show.Sesame GO is powered by the Kaltura MediaGo OTT Solution and can be accessed for US$3.99 (€2.89) per month or US$29.99 per year.Sesame Go is designed to provide an ad-free environment for children to watch Sesame Street, and offers the latest full-length TV episodes as well as “hundreds” of episodes from prior seasons.“Sesame GO provides families with a unique experience we have never offered before – a secure, ad-free environment with full-length Sesame Street TV episodes they can watch anytime and anywhere,” said Scott Chambers, Sesame Workshop’s senior vice president, worldwide media distribution.
Axios FutureWhat it is: A daily newsletter from Axios on developments in today’s most buzzworthy topics, from automation to blockchain to the gig economyWhy we love it: “All of Axios’s newsletters are designed for on-the-go trendsetters with limited attention spans. Everything you need to know about the latest news is encapsulated within the email (although there are links to more info if you’ve got the time). Axios Future goes out in the evenings, so it’s a nice way to recap the day.” — Liz Webber, insights editorMorning BrewWhat it is: A roundup of the day’s business and finance news, told with a strong mix of humor and market savvy.Why we love it: “I’ll be honest — I’m a business writer and editor, but I’m often so busy that I miss some of the day’s major stories. Then this email rolls into my inbox sometime past 6 a.m. every morning, and I feel instantly caught up. I’m consistently impressed with how they crunch complex stories down into quick-hit takeaways, with a strong sense of how the information is most useful (along with some strong puns and gifs).” — Jason Feifer, editor in chiefCB InsightsWhat it is: A free newsletter that covers VC funding, M&A, new patents and other bellwethers of tech industry shifts — and makes them relatable through mentions of vampires, March Madness and other cultural touchstones (about four days/week).Why we love it: “You read a lot about AI, blockchain, VR and emerging tech from the perspective of an analyst spewing anecdotes. CB Insights, on the other hand, has the data to back up its claims, which it presents in an entertaining style. No seriously, you don’t glaze over: It’s anything but dry. The company’s newsletter offers a mix of report summaries, stats and infographics and curated articles, and it’s available for free to a consumer audience about four times per week (and more frequently to enterprise customers who subscribe to full access to CBI’s research). CB Insights co-founder and CEO Anand Sanwal signs all of his letters, ‘I love you,’ and he’s not afraid to share his sense of humor. Case in point: The Oct. 9 newsletter began, ‘Today in Weird Isht That Teens Do,’ then went on to describe a new Instagram phenomenon.” — Lydia Belanger, associate editorRelated: 10 Books Every Aspiring Millionaire Must ReadCultureBanxWhat it is: Business, finance and tech news and its impact on people of color. Why we love it: “Offers great insights and a point of view you don’t always get from other news sources. For instance, in a story about the battle between Apple, Netflix and Amazon for streaming dominance, you’ll learn that African Americans are having an increasing influence on these platforms’ content because, as the writer explains, ‘Black people stream videos more frequently on all devices than the total U.S. population, according to Nielsen.'” — Dan Bova, digital editorial directorMy Sweet Dumb BrainWhat it is: Every week journalist Katie Hawkins-Gaar explores big topics around mental health, including grief, anxiety and depression, impostor syndrome and professional jealousy, and most of all, how to remember to be kind to yourself. Why we love it: “It’s like getting a letter from a friend that has been there and gets it. Hawkins-Gaar’s honest and deeply felt essays and useful tips and resources provide a framework to talk about things that are often so daunting to be open about, even with the people that you trust — especially if you feel like you have to have it all together, as so many entrepreneurs do.” — Nina Zipkin, staff writerRelated: 5 Books Billionaire Bill Gates RecommendsAutoweek Daily DriveWhat it is: Autoweek’s daily newsletter breaks down the top auto-related stories of the day, from new vehicle launches and reviews to technology and industry news.Why we love it: “Who wouldn’t love pics of the coolest new cars on the planet delivered to their inbox every morning? But it’s more than just shiny Ferraris and Lamborghinis. As cars and tech continue to shape the future of travel and commerce, the auto-obsessed experts at Autoweek condense the day’s biggest news into quick, easy-to-read stories. What’s that wily Elon Musk up to now? Be the first to know.” — Patrick Carone, special projects directorWall Street Journal What’s NewsWhat it is: The Wall Street Journal’s daily newsletter brings together political, business and cultural news in a digestible format.Why we love it: “The Wall Street Journal is a journalistic institution for a reason: it breaks a lot of news. If you want to learn about the latest in tech, business and politics, you may as well go straight to the source. The newsletter also collects interesting stories from other publications as well, and also features a story that happened that day in years past. While the newsletter is free, the Wall Street Journal’s website has a paywall.” — Stephen Bronner, news directorScienceWhat it is: Science magazine’s daily newsletter highlighting the latest news and trends in tech, space exploration, medical advances, climate research and more.Why we love it: “Did you know that Jupiter’s moon Europa has a subterranean ocean that might have extraterrestrial life swimming around in it, but that landing a NASA explorer there is problematic because the surface is covered in giant blades of spaceship-destroying ice? I didn’t until I started reading this newsletter. While I have no plans of getting into the space exploration biz, this kind of stuff gets me so inspired. Whether I’m learning about stars being ripped in half by black holes or new lifeforms being discovered at the depths of our oceans, this newsletter’s bite-size news briefs and amazing photos make me want to think bigger. And also? I’m counting on the editors to give me a heads up if a planet-killing asteroid heading our way and with that, permission to order extra bacon on my breakfast sandwich.” — Dan Bova, digital editorial directorRelated: How Frequently Should You Be Sending Out Your Email Newsletter?Hot PodWhat it is: A deep dive into the business of podcasting, from news to reported stories about trends and major changes.Why we love it: “I’m obsessed with podcasts — as a listener, a creator of two of them, and as a guy making his living in media. Podcasting is still emerging in every way: economically, creatively, technologically. And Nick Quah’s Hot Pod newsletter is the most insightful and informative look into the industry I’ve seen. This past week, for example, he led off with a deep dive into the weird manipulations that seem to be taking place on the iTunes charts. He had news of Spotify opening up its platform to more podcast creators, which instantly sent me into strategizing mode (only one of my shows is currently on there). And lots more. For anyone curious about how this industry works, how to make money in it, and where it’s going next, Hot Pod is the must-read.” — Jason Feifer, editor in chiefMorning Media NewsfeedWhat it is: AdWeek’s daily newsletter highlighting the latest news in media (print, digital, broadcast, telecommunications and business). Why we love it: “As a journalist, it’s vital for me to stay up to date on key trends in my industry — who’s hiring, who’s firing and which headlines have generated unprecedented amounts of buzz. But it’s equally relevant for any well-versed entrepreneur or high-ranking businessperson. The newsletter rounds up coverage from a host of outlets, covering everything from Elon Musk’s likely replacement as Tesla’s chairman to Snap Inc.’s launch of 12 original shows. (And that infamous Trump Administration op-ed? A morning heads-up on that was included, too.) For me, this weekday email does what I believe any successful newsletter should: ensure you’re never caught off-guard at the water cooler — or, more accurately, the coffeemaker — when someone brings up a pivotal piece of news.” — Hayden Field, associate editorEntrepreneurWhat it is: A daily feed of the top content on Entrereneur.com, as well as special deals on events and exclusive programs.Why we love it: “OK, fine, maybe I’m biased here, but this newsletter does an amazing job of highlighting the many voices, opinions and philosophies of our network of hundreds of contributors and staffers. There is a lot happening in the entrepreneurial world, and whether you are just getting started or have been at it since the day you were old enough to have a newspaper route, this gives you a fantastic overview of what’s going on out there.” — Dan Bova, digital editorial director Newsletters Free Webinar | July 31: Secrets to Running a Successful Family Business Learn how to successfully navigate family business dynamics and build businesses that excel. Next Article 11 Must-Read Newsletters for Entrepreneurs Image credit: BrAt_PiKaChU Entrepreneur Staff –shares October 12, 2018 Add to Queue Entrepreneur Staff Entrepreneur magazine and digital editors share their picks. 8 min read Register Now »
Source:https://www.southampton.ac.uk/news/2018/10/trans-atlantic-trial.page Reviewed by James Ives, M.Psych. (Editor)Oct 10 2018Children with an aggressive form of cancer are being given new hope in a world-first trans-Atlantic clinical trial that will test a new three-part treatment. The study, involving doctors and cancer scientists in Southampton, America and Germany, will boost the body’s immune system to kill off neuroblastoma, one of the most common childhood cancers.The Phase 1 trial is funded by UK charities Solving Kids’ Cancer (Europe), JACK and US charities Solving Kids’ Cancer and Band of Parents. It will be one of many to be conducted at the University of Southampton’s Centre for Cancer Immunology, which is the UK’s first and only centre dedicated to cancer immunology research. The centre recently opened at University Hospital Southampton, thanks to the University’s £25m fundraising campaign.Neuroblastoma affects around 100 children – mostly under the age of five – in the UK every year and develops from immature nerve cells. It usually starts as a tumour in the abdomen or chest, however, in many children, it spreads to other places in the body such as the bones and bone marrow.In those cases, less than half of patients are cured despite intensive treatment which includes surgery, chemotherapy, radiotherapy and stem cell transplants.More recently, a form of immunotherapy known as anti-GD2, which uses antibodies to lock onto cancer cells so the immune system can find, fight and destroy them, has shown the potential to improve survival rates.This new study, led by Dr Juliet Gray, Associate Professor of Paediatric Oncology at the University of Southampton, involves combining mIBG, a special form of targeted radiotherapy which delivers radioactive iodine directly to neuroblastoma cells, with two different antibody therapies for the first time.One of these therapies, Nivolumab, has shown exciting results in adult cancers. It blocks a harmful protein called PD-1 and gives patients’ own immune cells a boost so that they can be set free to kill tumour cells.The researchers will give Nivolumab alongside the currently-used anti-GD2 to target specific cancer cells while protecting normal healthy cells.Related StoriesNew protein target for deadly ovarian cancerHow cell-free DNA can be targeted to prevent spread of tumorsSugary drinks linked to cancer finds studyThe trial will be run from four centres – the University of Southampton’s Centre for Cancer Immunology, UCH, Madison Children’s Hospital, Wisconsin, and the University of Greifswald, Germany. It is also the first trial to be sponsored by University Hospital Southampton NHS Trust.”Immunotherapy with anti-GD2 has been shown to increase the number of children with neuroblastoma who stay in remission and has become a standard component of treatment – but sadly a large number of children still relapse and die from their disease,” explained University of Southampton’s Dr Gray who is also a consultant paediatric oncologist at Southampton Children’s Hospital.”Work in the laboratory has shown that combining these types of antibodies with radiotherapy is potentially a very powerful way of eradicating neuroblastoma tumours and these three different therapies appear to work together to generate strong, protective immunity to the tumour.”She added: “This trans-Atlantic trial will be the first time they have been tested together and we are hopeful the combination of treatments will substantially improve the cure rate of children with this form of cancer.”Stephen Richards, CEO of Solving Kids’ Cancer (Europe), said: “Cutting-edge clinical trials offer real hope for children with high-risk neuroblastoma and their families. The numbers of children affected are small, so funding collaborative international research is the only way we will improve survival rates and find a cure for this devastating disease.”The researchers plan to give an initial course of mIBG-targeted radiotherapy followed by Nivolumab and anti-GD2 over a period of six months. Although the initial stages of the treatment process will require children to be in hospital, it is hoped that the therapy will be well tolerated and will eventually be delivered largely on an outpatient basis.The trial’s objective is to ensure the combination is safe to deliver to children with neuroblastoma in order to develop further studies to compare it with current treatments.
The botulinum toxin injections were incredibly effective in decreasing pain levels, as well as patients’ use of pain medications, including opioids. Many of the women in our study reported that the pain had a profound effect on their quality of life, and this treatment may be able to help them get their lives back.”Pamela Stratton, M.D., a gynecologist and scientist at NINDS, who co-led the study with Barbara Karp, M.D., a neurologist and program director at NINDS Endometriosis occurs when the uterine tissue lining grows outside of the uterus and is estimated to affect up to 176 million women worldwide. It is an inflammatory condition that can lead to infertility and cause chronic pain. The usual gynecologic treatments include hormonal therapy and surgery to remove the growths. However, in many cases, pain returns after the interventions.In the study, women with surgically treated endometriosis who were generally taking hormones to suppress menses, but who continued to experience pain and had pelvic floor muscle spasm, initially received injections of botulinum toxin or saline as part of a placebo-controlled clinical trial, targeting areas of spasm. At least one month after the masked study injection, 13 participants chose to receive open-label botulinum toxin injections in areas that remained in spasm and were then followed for at least four months. These patients were described in the current study at the NIH Clinical Center.Related StoriesWar against mosquitoes saves lives and money in Sri LankaResearchers survey orthopedic providers to understand factors that drive opioid prescribing practicesNew computational model explores daily pain sensitivity rhythmsIn all participants, during follow-up, pelvic floor muscle spasm was not detected or occurred in fewer muscles. Within two months of receiving the injections, pain decreased in all of the participants, with 11 out of 13 subjects reporting that their pain was mild or had disappeared. Additionally, usage of pain medication was reduced in more than half of the participants. Prior to receiving toxin injections, eight participants reported moderate or severe disability and after treatment, six of those patients noted an improvement.The participants experienced a decrease in muscle spasm and had pain relief that resulted in less disability and less use of pain medication. These findings suggest that pelvic floor muscle spasm may be experienced by women with endometriosis and contribute to pain persisting after standard treatment. Importantly, the beneficial effects were long-lasting, with many patients reporting pain relief lasting at least six months.Botulinum toxins, such as Botox, work by blocking the nerve signals for muscles to contract and have been used to treat migraines and certain movement disorders. Previous research has suggested that botulinum toxin may help women experiencing other types of chronic pelvic pain, but this treatment had not been studied in women with endometriosis.”We know that many doctors are using botulinum toxin to help their patients, but everyone uses slightly different techniques and methods, including different brands of toxin and various doses. This study will begin to provide rigor to help ensure standardized protocols and treatment in pelvic pain,” said Dr. Karp.Larger clinical studies will need to confirm the current findings. In addition, future research will focus on the mechanisms underlying chronic pelvic pain and better understanding of ways in which botulinum toxin may help treat those disorders. Source:NIH/National Institute of Neurological Disorders and StrokeJournal reference:Tandon, H.K. et al. (2019) Botulinum toxin for chronic pelvic pain in women with endometriosis, a cohort study of a pain-focused treatment. Regional Anesthesia & Pain Medicine. doi.org/10.1136/rapm-2019-100529. Reviewed by Kate Anderton, B.Sc. (Editor)Jul 11 2019Pelvic pain associated with endometriosis often becomes chronic and can persist (or recur) following surgical and hormonal interventions. According to results published in Regional Anesthesia & Pain Medicine, treating pelvic floor muscle spasm with botulinum toxin may relieve pain and improve quality of life. The study was conducted by scientists at the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.
Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: T-Mobile’s magenta semitruck hits the road to showcase 5G technology (2018, August 11) retrieved 18 July 2019 from https://phys.org/news/2018-08-t-mobile-magenta-semitruck-road-showcase.html ©2018 The Seattle Times Distributed by Tribune Content Agency, LLC. T-Mobile’s next magenta-heavy, super-visible campaign won’t be encouraging customers to switch to the company’s cellphone service. Instead, the Bellevue, Wash., carrier plans to take a decked-out semitruck around the country to showcase its ideas for the next generation of wireless connectivity, 5G, and how it envisions people and businesses making use of it. Credit: CC0 Public Domain Nokia to help with T-Mobile superfast telecom network The truck is an extension of the company’s Tech Experience lab, now sprawling throughout the second floor of T-Mobile’s wireless development lab in Bellevue, a few miles north of its Factoria headquarters.Inside that Bellevue showcase, an employee bounces a soccer ball (guess what color) in front of a line of cellphones. Half the phones are set up on the 4G LTE network, the current standard for phones, and the other half are simulating the upcoming 5G technology. Mirrored in the line of phones, the image of the ball follows reality a fraction of a second later on the 5G phones. The LTE phones quickly catch up, but it’s noticeably later.”5G has more speed, more capacity,” said Karri Kuoppamaki, the company’s vice president overseeing 5G strategy.Another demo shows normal labels on wine bottles transforming into talking T-Mobile executives when an app is scanned over them. On a balcony adjacent to the lab, an LTE-connected drone soars into the air, a small demonstration of a larger test the company is conducting with FAA approval in Reno.The lab is not open to the public, rather it’s designed for business partners, researchers and students to get a sense of how 5G and other wireless technology works and their possibilities.Most of the flashy demos inside the Tech Experience lab don’t exist in the wild yet, and won’t until next year at the earliest. T-Mobile, like its two larger competitors, is building out infrastructure and testing 5G connections in select cities so some capabilities will be ready when phones equipped to handle the next generation of wireless service are released next year.T-Mobile, which has about 6,800 employees in the Puget Sound area, made a deal earlier this year to merge with the fourth-largest wireless carrier, Sprint. The pact is winding its way through U.S. regulatory approvals.Throughout the deal process, the companies’ third attempt to merge, T-Mobile has emphasized that the two will have much stronger 5G technology as a combined entity, rather than separately.T-Mobile plans to make 5G available in a limited capacity in about 30 cities next year using spectrum it won in a federal auction last year. It has pledged to bring the technology nationwide in 2020.U.S. carriers have big plans for 5G—seamless virtual reality on phones, video downloads in seconds, maybe even remote surgical procedures one day. It’s getting closer, but executives remain rooted in reality.Everything will one day be connected, T-Mobile Chief Technology Officer Neville Ray said in an email, but it won’t all happen next year.”Consumers will first begin to experience 5G when devices become available in 2019, but again, just like LTE, it will evolve and change over time,” he wrote. “Some of the visionary 5G experiences we showcase in the Tech Experience and on the truck are likely next decade.”T-Mobile has taken its truck on the road, with its first stop in Philadelphia.
COMMENTS Published on The proposed fisheries harbour at Kulai in Mangaluru taluk will be able to accommodate around 350 fishing boats, according to Nalin Kumar Kateel, Member of Parliament from Dakshina Kannada. Addressing presspersons here on Monday, Kateel said the number of fishing boats in the region has increased over the years. Old Mangalore Port is the only fisheries harbour in the taluk as of now. He said the Centre has decided to take up the construction of fisheries harbour at Kulai, near New Mangalore Port, at a cost of ₹196 crore. When Union Shipping Minister Nitin Gadkari was informed of the importance of the project for coastal Karnataka, he agreed to include it under the Sagarmala project. Of the total project cost, 45 per cent will be contributed by the New Mangalore Port Trust (NMPT), and 5 per cent by the State government. The remaining amount will be contributed by the ministries concerned under the Sagarmala project, Kateel said. Gadkari will lay the foundation stone for the project through videoconferencing on Tuesday. Kateel said NMPT will manage the fisheries harbour project at Kulai in Mangaluru taluk. To be located 4.5 km north of New Mangalore Port, the Kulai fisheries harbour will come up on an area of 11 acres. The Union Shipping Ministry has set May 2022 as the target month for the completion and commissioning of the fisheries harbour.Breakwater construction will be taken up under the phase 1 of the project. Tender has already been awarded for the construction of the breakwater, Kateel added. March 04, 2019 SHARE SHARE EMAIL fishing industry SHARE COMMENT Karnataka