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Botulinum Toxin Deactivated by One Slight Change

first_imgA researcher at Brookhaven National Laboratory mutated a botulinum enzyme by just one amino acid, and abolished its toxicity.  The mutation, a change from a glutamate to a glutamine at one position, increased the distance from a zinc atom to a water molecule by 0.6 angstrom, less than one tenth of a billionth of a meter.  This was enough to prevent the botulinum enzyme from cleaving its target protein, a neurotransmitter.  The modified enzyme could still bind to it, but not cleave it.This experiment points out the specificity of enzymes.  We are led to believe that evolution works by mutating things recklessly, but look how slight a change totally disarmed this enzyme.  A second observation is that toxins like botulinum might have originally had a beneficial function, but became toxic through degenerative mutations.  Though difficult to prove, it is an interesting suggestion that, just as with mentally ill humans, it doesn’t take much to turn a benign individual into a killer.  That isn’t evolution.  It’s a breakdown in quality control.  Another possibility is that botulinum’s function, cleaving a neurotransmitter, was originally beneficial.  As reported before, many deadly poisons actually follow a “hormesis” curve and only become harmful above certain levels (see 02/12/2003 headline).  Botox is now all the rage.  In minute amounts, it is proving versatile for everything from beauty treatments to tumor reduction; see for instance this report on EurekAlert about University of Pittsburgh scientists using to ease symptoms of enlarged prostate.(Visited 14 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

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Billions for water infrastructure projects

first_img20 May 2011South Africa plans to spend over R14.2-billion over the next three years on dams and water distributions systems to ensure the country maintains a sustainable water supply, says Water and Environmental Affairs Minister Edna Molewa.The spending forms part of the government’s three-year, R846-billion infrastructure upgrade plan.Addressing members of Parliament in Cape Town this week, Molews said her department had spent R5.9-billion of the R29.2-billion budgeted for several projects, ranging from water services projects to mega infrastructure projects.“The spending focus over the medium term will be on bulk raw water resource infrastructure to meet sustainable demand for South Africa,” Molewa said, pointing out that the details are outlined in Vote 38 in the National Treasury’s Estimates of National Expenditure for 2011.Included in the R14.2-billion, the department would also spend R1.4-billion on small infrastructure projects, over R6.4-billion on regional bulk infrastructure and R730-million on water services projects.Mega-infrastructure projectsThe projects include R16-billion for the Olifants River Water Resource Development Project in Limpopo – which includes over R3-billion to be spent on the De Hoop Dam and a further R13.1-billion on distribution systems.So far over R2.5-billion has been spent on the project – the bulk (over R2.1-billion) on revamping the De Hoop Dam. A further R2.8-billion will be spent on the project over the next three years.The other mega-infrastructure projects the department is rolling out include:A R2.2-billion upgrade of Clanwilliam Dam (with R380-million to be spent over the next three years).The R2-billion Greater Letaba River Project which includes the Tzaneen and Nwamitwa dams (R386-million over the next three years).Phase one of the Mokolo and Crocodile River Augmentation Project (R603-million over the next three years).The R1.7-bn Nandoni Water Treatment Works and Distribution project (R753-million over the next three years).The Nandoni Pipeline project (R720-million over the next three years).Source: BuaNewslast_img read more

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Generika-Ayala routs Cignal for PSL All-Filipino bronze

first_imgGilas experience gives Abu Tratter edge in PBA Draft Hotel management clarifies SEAG footballers’ kikiam breakfast issue “And I told the management that we can’t keep changing the roster because we have to retain this core since the players already had the chemistry.”Meneses added that the team has a legitimate chance at the title in “two years” and the bronze medal in this conference was just part of their title chase in the future.Patty Orendain finished with 16 points for the Lifesavers to lead all scorers while Angeli Araneta and Ceballos had 13 and 10 points, respectively.Royse Tubino led the HD Spikers with 15 points while Rachel Ann Daquis had 10.ADVERTISEMENT Photo by Tristan Tamayo/INQUIRER.netMANILA, Philippines—Generika-Ayala subdued Cignal in straight sets, 25-12, 30-28, 25-13, to claim the bronze medal in the Philippine Superliga All-Filipino Conference Saturday at Mall of Asia Arena.This is the best finish of the Lifesavers in four years or since they won the title in the 2014 All-Filipino Conference when they joined forces with Philippine Army.ADVERTISEMENT The Lifesavers held a slim 12-10 lead in the third but was able to quickly gain momentum going on an 8-2 run to take a 20-12 lead.Fiola Ceballos then, scored on back-to-back aces to finish off the HD Spikers.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSUrgent reply from Philippine ‍football chiefGenerika-Ayala head coach Sherwin Meneses said his team has slowly turned itself around and gradually built a chemistry that could help them compete for the championship in the near future.“The first conference was okay because we had an import but the players didn’t know each other very well,” said Meneses in Filipino. Private companies step in to help SEA Games hosting Is Luis Manzano planning to propose to Jessy Mendiola? PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss LATEST STORIES LOOK: Joyce Pring goes public with engagement to Juancho Triviñocenter_img MOST READ SEA Games: Biñan football stadium stands out in preparedness, completion View comments SEA Games: Biñan football stadium stands out in preparedness, completion TS Kammuri to enter PAR possibly a day after SEA Games opening Don’t miss out on the latest news and information. Lacson: 2019 budget delay due to P75-B House ‘insertion’ Sports Related Videospowered by AdSparcRead Nextlast_img read more

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Pochettino warns fullstrength Spurs can challenge for league title

first_imgTottenham manager Mauricio Pochettino suggests that his side may be able to maintain their unexpected Premier League title till the end once at full-strength.Despite the absences of star duo Harry Kane and Dele Alli for over a month and a lack of signings across the past two transfer windows, Spurs have stayed in the mix with Manchester City and Liverpool for the league title this season.The Lilywhites have won four games in a row now following last week’s impressive 3-0 Champions League triumph over Bundesliga leaders Borussia Dortmund.But Pochettino thinks there may still be something left in the tank from his squad once his injured players have returned.“I am so happy and feel so proud of my squad,” Pochettino told Sky Sports. “From the beginning of the season no one believed we could repeat last season.Harry Maguire, Manchester UnitedLiverpool legend Nicol slams Harry Maguire’s Man United form Andrew Smyth – September 14, 2019 Steve Nicol believes Harry Maguire has made some “horrendous mistakes” recently, and has failed to find his best form since joining Manchester United.“[But] we are where we are because we deserve to be there. We’ve competed very well in the last few months, got the results we wanted and kept a very good position in the table while being involved in the Champions League.“With all the things [that have been] against us we were fighting, and we are going to fight in the future to be in a very good position and try to win.“But, of course, the moment we have the whole squad available we are going to be stronger than before.“We will see, if we are able to arrive in the last few months in a good position, that is the moment to push and to achieve the things that we want.”Spurs will take a trip to Turf Moor on Saturday to take on Burnley in their next Premier League match.Victory this weekend will enable Pochettino’s men to close up to two points within City, who will be facing Chelsea in the Carabao Cup instead, in third-place.LONDON, ENGLAND – JANUARY 30: (EDITOR’S NOTE: Digital filters have been used) The corner flag is pictured prior to the Premier League match between Tottenham Hotspur and Watford FC at Wembley Stadium on January 30, 2019 in London, United Kingdom. (Photo by Mike Hewitt/Getty Images)last_img read more

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EE Times Group Buys Electronic Design Conference

first_imgUnited Business Media’s EE Times Group has acquired electronic design market event DesignCon as well as its database of more than 30,000 records from Professional Education International. Financial terms were not disclosed.EE Times says the purchase expands its event portfolio into adjacent markets including chip-level system design and verification, analog and mixed-signal design and verification and IP re-use and integration. EE Times also produces the Embedded Systems Conference. Both conferences will be led by David Blaza, who serves as vice president of events and embedded systems. Professional Education International president John Janowiak will continue to serve as a consultant in an advisory role to EE Times Group, the company says. As part of the deal, EE Times Group also is acquiring the PCB Summit and IP Summit, two DesignCon co-located events. Also included in the deal is InfoVault, a member based Web site featuring a technical library, video and additional content covering the same markets as DesignCon.Last year, DesignCon generated approximately $1 million in revenue, an EE Times spokesperson says. The next DesignCon is scheduled for January 31 to February 3, 2011 in Silicon Valley.last_img read more

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Post Malone Nicki Minaj To Headline Made In America Fest

first_img Post Malone, Nicki Minaj To Headline Made In America Fest News Labor Day weekend in Philadelphia promises a musical blast worthy of wrapping up what looks to be an epic summer of festivalsPhilip MerrillGRAMMYs Jun 4, 2018 – 1:28 pm Need some plans for Labor Day 2018 weekend? Philadelphia’s Made In America fest looks like the place to be, following the announcement of its performer lineup for Sept. 1–2, with Nicki Minaj and Post Malone headlining.As if the headliners weren’t enough enticement, Meek Mill will make his first hometown Philly performance since his release from incarceration. GRAMMY winners joining the fun include Alessia Cara, Diplo, Miguel, and Zedd.Malone collaborator Ty Dolla Sign is also part of the MIA lineup, in addition to GRAMMY nominees 6lack, Fat Joe, and Janelle Monáe. Bloodpop, Hobo Johnson & The Lovemakers, and Tokimonsta are just a few of the emerging talents sure to make MIA a fitting finale for summer this Labor Day weekend.Malone’s 2018 album Beerbongs & Bentleys arrived in April and has been breaking streaming records, while Minaj’s new album Queen is expected on June 15. The song “Ball For Me” on Malone’s Beerbongs & Bentleys features Minaj and was co-written by them with producer Louis Bell.VIP and Tidal pre-sale tickets are available now. Visit the festival’s website for more ticket information.Catching Up On Music News Powered By The Recording Academy Just Got Easier. Have A Google Home Device? “Talk To GRAMMYs”Read more Facebook Post Malone, Nicki Minaj Headline Made In America post-malone-nicki-minaj-headline-made-america-fest Email Twitter last_img read more

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Oppo F11 Pro takes to India with a 48megapixel rear camera

first_imgOppo The latest phone in Oppo’s F series lineup is promising to dazzle you with beautiful photos. And its 48-megapixel rear camera lives up to that promise.That rear camera is paired with a 5-megapixel depth sensor. And together the F11 Pro’s cameras do a great job of capturing images with plenty of detail, letting you zoom right down to the pixels. There’s also a night mode and the phone uses color mapping to identify and reconstruct the colors of a scene, which should help take better looking portrait shots. Oppo says it can even take great low-light portrait shots, a claim I’ve also tested. Oppo’s used AI to improve the phone’s camera features — the company claims it can recognize over 23 types of scenes and is capable of choosing the right settings to get the most out of a picture. Camera aside, the phone is quite the looker. The rear design has a gradient look that’s now a hallmark of Chinese phone makers, and it’s stunning. The pop-out front camera is placed in the middle and features a transparent design inspired by amber, which helps keep the focus on the 6.53-inch display — and Oppo says the screen uses its own memory (RAM) to help reduce power consumption.Oppo’s also designed the phone to make it easier to hold. The F11 Pro has a crescent design on the top and bottom and its rounded edges don’t dig into your palms. This should make it comfortable to hold and play games on. Phones Tags 0 Post a commentcenter_img Share your voice Following fans’ feedback on previous phones, Oppo has moved the speaker and microphone. The microphone is now in the middle of the phone, making it easier to pick up your voice if you’re playing a game and holding the phone horizontally.Other cool features include fast charging, which Oppo says can get the F11 Pro from 0 to full in just 80 minutes. Factor in the 4,000-mAh battery and the phone seems fit for all-day use. Note that the F11 doesn’t use a Qualcomm chip: It’s powered by an octa-core MediaTek Helio P70 instead. But I reckon it should hold up well against Qualcomm Snapdragon 660-powered phones.The F11 Pro runs Android 9 Pie, but it uses Oppo’s own ColorOS 6 on top. Unlike Vivo phones, it doesn’t just shoehorn in its own gesture control. It also includes Android P gesture controls, so you can find what works for you. The Smart Sidebar feature brings full-screen multitasking to the F11 Pro. Turn it on by swiping to the left from the right side. You can launch apps from the Smart Sidebar, quickly share recently opened files, start screen recording or snap a screenshot. Oppo’s latest F series phone isn’t a crazy high-end flagship phone, but it’s a solid midrange device. The F11 Pro is expected to hit markets in India first, then China and the rest of Asia pretty soon. But there’s no word on a US, UK or Australia launch. The 4GB RAM with 128GB of storage model will retail for around $285 converted (that’s £215 and AU$400) while the 6GB RAM with 64GB of onboard storage will go for around $355.Quick specsProcessor: MediaTek Helios P70 octa-core Memory: 6GB RAM, 64GB or 128GB onboard storageDisplay: 6.53-inch full-HD+ (2,340×1,080 pixels)Camera: Dual 48-megapixel and 5-megapixel rear, 16-megapixel f/2.0 frontBattery: 4,000-mAh battery with fast charging Oppolast_img read more

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Railway Budget 2013 Unplugged Pawan Bansals First and Last Choice

first_imgOpinions on Railway Minister Pawan Kumar Bansal’s Railway Budget 2013 may differ from person to person, but on a closer look, he has presented a good budget considering the current financial situation of the Indian Railways and the forthcoming elections next year.In fact, Bansal has taken a few praiseworthy steps towards narrowing down the deficit gap in the struggling Indian Railways without disappointing the common man and at the same time appeasing the industrial sector.Many may questioned if Bansal’s Railway Budget 2013 was too financial discipline and avoided taking bold steps, including hiking passenger fare, keeping in mind next year’s elections and not to disappoint the public who were irked by rail fare hike last month. He is also been criticized for introducing lesser new rail lines compared to previous years.But on a closer look, Bansal has cleverly hiked the passenger fares, though indirectly, and would do so in the future though he abstained from increasing the figure in his budget. The public will indirectly pay more through ticket cancellation, clerkage and tatkal charges. Supplementary charges for super fast trains have also been marginally raised. The cost of travelling on train too may go up as the railway minister hinted a possible annual hike of 5 percent for various kinds of services.The public may also have to pay more in the future depending on the flatuating fuel price as the government is implementing Fuel Adjustment Component (FAC) linked revision for freight tariff from 1st April 2013. The railway minister said that the move could increase the cost of commodities by 4-8 paise per kg but additional revenue to the Railways will be around ₹4,200 crore.Bansal’s Railway Budget has many positive things that his predecesors didn’t think of. The announcement that a loan of ₹3,000 cr taken in 2011-12 has been fully repaid along with interest should come as a welcomed move. He also promised that the Railways will make profit by the end of the financial year.He announced the Indian Railways will set up an exclusive Centralized Training Institute at Secunderabad – Indian Railways Institute of Financial Management (IRIFM), indicating his long-term plan for the Railways.Bansal’s Railway Budget will also please investors, as much modernization projects of the railways will be done through Public-Private Partnership (PPP) route. Target of ₹1000 crore each fixed for Rail Land Development Authority and IR Station Development Corporation to be raised through PPP in 2013-14. Of the planned investment of Rs 63,363 crore for the financial year, ₹6000 crore will be under PPP mode.Many may not be happy for not introducing many new rail lines as expected but several measures announced in the budget like – safety, cleanliness and hygiene, special provision for women passengers and differently abled persons, introduction of Train Protection Warning System on Automatic Signalling Systems, elimination of 10797 level crossings to curb accidents, introduction of Self Propelled Accident Relief Trains, introduction of next-gen e-ticketing system that can handle 7200 tickets per minute as against the present 2000, and several others are necessary and will help the Railways in the long run.Bansal’s Railway Budget 2013 should be considered as a clever one.last_img read more

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Vijay Mallya brutally humiliated at The Oval in London booed with Mallya

first_imgVijay Mallya, son Siddharth MallyaTwitterIndian businessman Vijay Mallya found himself in a terrible situation when he walked out of the Kennington Oval in London after watching India and Australia World Cup match on Sunday.In a video that has been doing the rounds of social media, Mallya can be seen surrounded by a bunch of Indians who couldn’t stop booing the beleaguered businessman for leaving India on March 2, 2016 after defaulting on loans amounting to Rs 9,000 crore.Chants like “Mallya Mera Paisa De”, “Chor Hai Chor Hai” and “Gali Gali Me Shor Hai, Vijay Mallya Chor Hai” resounded in Mallya’s ears as he started walking towards his car after the match. He did turn back and responded to a few people with a “Thank You.” At one point, a shout of “Be a man, apologise to your country” is heard, to which his response is inaudible. However, the viral video divided people on Instagram. While a majority of people said that Vijay Mallyadeserved this kind of treatment wherever he goes, a certain section felt that it was a shameful act by the people to humiliate someone like this.Mallya has repeatedly denied fleeing the country, saying he is ready to pay back the money he owed to the Indian banks. India had in 2017 filed for Mallya’s extradition, which he contested. He is out on bail.A consortium of 13 banks, led by the State Bank of India (SBI), has initiated loan recovery proceedings against him. The proceedings are on before a special court in Mumbai under the Fugitive Economic Offenders Act.The Enforcement Directorate (ED) had also moved the Special Prevention of Money-Laundering Act Court last year to get Mallya declared a “fugitive economic offender” and confiscate his properties, estimated at more than Rs 12,000 crore, making it the first such case of its kind under the new law.Take a look. Vijay Mallya trolledInstagram Vijay Mallya trolledInstagram Vijay Mallya trolledInstagram Vijay Mallya trolledInstagram (With IANS Inputs)last_img read more

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