Tag: 上海千花网

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Go West The south west corner of the continent aff

first_imgGo WestThe south west corner of the continent affords a magnificent coastline and is home to world-class vineyards and gourmet produce. With A&K’s ‘Gourmet South West’ journey you can visit Margaret River, the nation’s largest wine producing region. Allow yourself to be chauffeured from vineyard to vineyard, whilst you meet vignerons, enjoy a private barrel tasting and sample the local drop. Continue your journey on the Valley of the Giants Treetop Walk where you can take in the views from some of tallest timbers on earth, the tingle trees. This intimate journey will be an unforgettable experience.A&K’s seven-day private journey ‘The Gourmet South West’ from $3225 per person. The Apple IsleHistoric villages, seaside towns, fine food and exquisite boutique accommodation makes Tasmania a rewarding getaway. Though small in size, Tasmania is rich in culinary and cultural invention. A&K’s eight-day private journey ‘Tasmania on a platter’ showcases the highlights. With private wine tastings, picnic hampers showcasing local produce, artisan chocolate and berry tastings, there promises to be an abound of gourmet experiences. There is also a dinner at Saffire Freycinet’s award-winning Palate and a degustation lunch with matching wines at The Source restaurant at MONA. There is a world of ancient landscapes, abundant wildlife, deserted islands, wild bushland and secluded beaches to explore.A&K eight-day private journey ‘Tasmania on a platter’ is priced from $6050 per person. New ZealandA short hop across the water and you will find yourself surrounded by the landscapes of New Zealand. No matter which part of the country you visit, the glaciers, alpine peaks, volcanoes or rich pastoral land, the scenery is breathtaking. If you’re an adventure seeker – there are plenty of activities to engage with including bush walking, kayaking, sailing and fishing. A&K’s six-night private journey from Christchurch to the Marlborough Sounds grants you access to exceptional vineyards and hiking trails off the coastal Queen Charlotte Track. Luxury boutique accommodation is included at The George, Christchurch, Bay of Many Coves Resort and Edenhouse, Nelson.A&K’s six-night private journey ‘Christchurch to the Marlborough Sounds’ starts from $4285 per person. Go back to the e-newsletter Papua New GuineaExperience Papua New Guinea in style on board the True North adventure cruise ship, which departs from Cairns and Darwin. Sailing through the rivers, you will see the jungles, marine parks and volcanoes. A&K’s 11-night cruise from the Bismarck Sea allows you to discover the rarely-visited Lousiade Archipelago. Snorkel over submerged tanks and aircrafts lost during World War II, explore the rainforests and waterfalls of the highlands and share the Karawari River waterways with local boatmen. For a truly unique cultural experience, book a private journey with A&K.A&K’s 11-night Papua New Guinea cruise departs 30 November 2017; 27 November 2018.Prices from $20,995 per person twin share. Australians are considered to be inveterate travellers, the geographical remoteness and sheer size of the country certainly contributes to this nature. Melbournians will venture on a nine-hour road trip, whereas Sydney-siders will willingly board a long haul flight to Europe. Put simply, Australians are well versed at enduring long-haul trips in order to uncover cultural gems.For those who would like to limit the travel-time and allow more time for uncovering unique experiences, consider a private journey with Abercrombie & Kent, which offers plenty of journeys that take under five hours to reach, making a luxury escape all the more accessible. Gourmet QueenslandQueensland’s Scenic Rim is a little-known haven with wineries and scenery located south of Brisbane. Enjoy digs and award-winning cuisine with A&K’s ‘Queensland Gourmet Getaway’. Staying at Spicers Peak Lodge and Spicers Clovelly Estate, food is the focus. Spicers Peak Lodge delivers a degustation dinner plus a three-course lunch in the Granite Belt wine region with matching wines. Meanwhile Spicers Clovelly Estate has a French-inspired degustation menu at the Long Apron Restaurant, as well as a Thai cooking class and a three-course dinner of local produce. There are visits to boutique wineries, a spa treatment, plus a host of outdoor activities.A&K’s five-day private journey ‘Queensland Gourmet Getaway’ from $2380.Go back to the e-newsletterlast_img read more

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Dutch cable operator Ziggo confirmed that it is ba

first_imgDutch cable operator Ziggo confirmed that it is back in talks with Liberty Global, after rejecting a preliminary takeover offer from the firm back in October.Responding to “recent market statement,” Ziggo said that further to its October statement it is “currently in discussions with Liberty Global regarding a potential offer for the company by Liberty Global.”“Further announcements will be made if and when relevant. There is no certainty that any agreement can be reached or that any offer will ultimately be made,” said the firm.In October, Ziggo said it had received a “preliminary proposal regarding a potential offer” from Liberty, but said that this offer was “considered inadequate.”Liberty already holds a 28.5% stake in Ziggo and, according to reports this week, a potential takeover could value the firm at more than €6 billion.News of the discussions sent Ziggo’s share price up by more than 7% during trading today.The approach marks the latest takeover attempt by Liberty Global, which agreed to buy the UK’s Virgin Media earlier this year for €17.2 billion.last_img read more

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11 MustRead Newsletters for Entrepreneurs

first_img Axios FutureWhat it is: A daily newsletter from Axios on developments in today’s most buzzworthy topics, from automation to blockchain to the gig economyWhy we love it: “All of Axios’s newsletters are designed for on-the-go trendsetters with limited attention spans. Everything you need to know about the latest news is encapsulated within the email (although there are links to more info if you’ve got the time). Axios Future goes out in the evenings, so it’s a nice way to recap the day.” — Liz Webber, insights editorMorning BrewWhat it is: A roundup of the day’s business and finance news, told with a strong mix of humor and market savvy.Why we love it: “I’ll be honest — I’m a business writer and editor, but I’m often so busy that I miss some of the day’s major stories. Then this email rolls into my inbox sometime past 6 a.m. every morning, and I feel instantly caught up. I’m consistently impressed with how they crunch complex stories down into quick-hit takeaways, with a strong sense of how the information is most useful (along with some strong puns and gifs).” — Jason Feifer, editor in chiefCB InsightsWhat it is: A free newsletter that covers VC funding, M&A, new patents and other bellwethers of tech industry shifts — and makes them relatable through mentions of vampires, March Madness and other cultural touchstones (about four days/week).Why we love it: “You read a lot about AI, blockchain, VR and emerging tech from the perspective of an analyst spewing anecdotes. CB Insights, on the other hand, has the data to back up its claims, which it presents in an entertaining style. No seriously, you don’t glaze over: It’s anything but dry. The company’s newsletter offers a mix of report summaries, stats and infographics and curated articles, and it’s available for free to a consumer audience about four times per week (and more frequently to enterprise customers who subscribe to full access to CBI’s research). CB Insights co-founder and CEO Anand Sanwal signs all of his letters, ‘I love you,’ and he’s not afraid to share his sense of humor. Case in point: The Oct. 9 newsletter began, ‘Today in Weird Isht That Teens Do,’ then went on to describe a new Instagram phenomenon.” — Lydia Belanger, associate editorRelated: 10 Books Every Aspiring Millionaire Must ReadCultureBanxWhat it is: Business, finance and tech news and its impact on people of color. Why we love it: “Offers great insights and a point of view you don’t always get from other news sources. For instance, in a story about the battle between Apple, Netflix and Amazon for streaming dominance, you’ll learn that African Americans are having an increasing influence on these platforms’ content because, as the writer explains, ‘Black people stream videos more frequently on all devices than the total U.S. population, according to Nielsen.'” — Dan Bova, digital editorial directorMy Sweet Dumb BrainWhat it is: Every week journalist Katie Hawkins-Gaar explores big topics around mental health, including grief, anxiety and depression, impostor syndrome and professional jealousy, and most of all, how to remember to be kind to yourself. Why we love it: “It’s like getting a letter from a friend that has been there and gets it. Hawkins-Gaar’s honest and deeply felt essays and useful tips and resources provide a framework to talk about things that are often so daunting to be open about, even with the people that you trust — especially if you feel like you have to have it all together, as so many entrepreneurs do.” — Nina Zipkin, staff writerRelated: 5 Books Billionaire Bill Gates RecommendsAutoweek Daily DriveWhat it is: Autoweek’s daily newsletter breaks down the top auto-related stories of the day, from new vehicle launches and reviews to technology and industry news.Why we love it: “Who wouldn’t love pics of the coolest new cars on the planet delivered to their inbox every morning? But it’s more than just shiny Ferraris and Lamborghinis. As cars and tech continue to shape the future of travel and commerce, the auto-obsessed experts at Autoweek condense the day’s biggest news into quick, easy-to-read stories. What’s that wily Elon Musk up to now? Be the first to know.” — Patrick Carone, special projects directorWall Street Journal What’s NewsWhat it is: The Wall Street Journal’s daily newsletter brings together political, business and cultural news in a digestible format.Why we love it: “The Wall Street Journal is a journalistic institution for a reason: it breaks a lot of news. If you want to learn about the latest in tech, business and politics, you may as well go straight to the source. The newsletter also collects interesting stories from other publications as well, and also features a story that happened that day in years past. While the newsletter is free, the Wall Street Journal’s website has a paywall.” — Stephen Bronner, news directorScienceWhat it is: Science magazine’s daily newsletter highlighting the latest news and trends in tech, space exploration, medical advances, climate research and more.Why we love it: “Did you know that Jupiter’s moon Europa has a subterranean ocean that might have extraterrestrial life swimming around in it, but that landing a NASA explorer there is problematic because the surface is covered in giant blades of spaceship-destroying ice? I didn’t until I started reading this newsletter. While I have no plans of getting into the space exploration biz, this kind of stuff gets me so inspired. Whether I’m learning about stars being ripped in half by black holes or new lifeforms being discovered at the depths of our oceans, this newsletter’s bite-size news briefs and amazing photos make me want to think bigger. And also? I’m counting on the editors to give me a heads up if a planet-killing asteroid heading our way and with that, permission to order extra bacon on my breakfast sandwich.” — Dan Bova, digital editorial directorRelated: How Frequently Should You Be Sending Out Your Email Newsletter?Hot PodWhat it is: A deep dive into the business of podcasting, from news to reported stories about trends and major changes.Why we love it: “I’m obsessed with podcasts — as a listener, a creator of two of them, and as a guy making his living in media. Podcasting is still emerging in every way: economically, creatively, technologically. And Nick Quah’s Hot Pod newsletter is the most insightful and informative look into the industry I’ve seen. This past week, for example, he led off with a deep dive into the weird manipulations that seem to be taking place on the iTunes charts. He had news of Spotify opening up its platform to more podcast creators, which instantly sent me into strategizing mode (only one of my shows is currently on there). And lots more. For anyone curious about how this industry works, how to make money in it, and where it’s going next, Hot Pod is the must-read.” — Jason Feifer, editor in chiefMorning Media NewsfeedWhat it is: AdWeek’s daily newsletter highlighting the latest news in media (print, digital, broadcast, telecommunications and business). Why we love it: “As a journalist, it’s vital for me to stay up to date on key trends in my industry — who’s hiring, who’s firing and which headlines have generated unprecedented amounts of buzz. But it’s equally relevant for any well-versed entrepreneur or high-ranking businessperson. The newsletter rounds up coverage from a host of outlets, covering everything from Elon Musk’s likely replacement as Tesla’s chairman to Snap Inc.’s launch of 12 original shows. (And that infamous Trump Administration op-ed? A morning heads-up on that was included, too.) For me, this weekday email does what I believe any successful newsletter should: ensure you’re never caught off-guard at the water cooler — or, more accurately, the coffeemaker — when someone brings up a pivotal piece of news.” — Hayden Field, associate editorEntrepreneurWhat it is: A daily feed of the top content on Entrereneur.com, as well as special deals on events and exclusive programs.Why we love it: “OK, fine, maybe I’m biased here, but this newsletter does an amazing job of highlighting the many voices, opinions and philosophies of our network of hundreds of contributors and staffers. There is a lot happening in the entrepreneurial world, and whether you are just getting started or have been at it since the day you were old enough to have a newspaper route, this gives you a fantastic overview of what’s going on out there.” — Dan Bova, digital editorial director Newsletters Free Webinar | July 31: Secrets to Running a Successful Family Business Learn how to successfully navigate family business dynamics and build businesses that excel. Next Article 11 Must-Read Newsletters for Entrepreneurs Image credit: BrAt_PiKaChU Entrepreneur Staff –shares October 12, 2018 Add to Queue Entrepreneur Staff Entrepreneur magazine and digital editors share their picks. 8 min read Register Now »last_img read more

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Couse of cannabis and tobacco associated with worse functioning problematic behaviors

first_imgReviewed by Kate Anderton, B.Sc. (Editor)Apr 29 2019More than a third of young adults report using both cannabis and tobacco or nicotine products, providing a unique challenge to public health officials as cannabis is legalized in more jurisdictions, according to a new RAND Corporation study.Studying a group of young adults from California, researchers examined the many different ways that cannabis and tobacco or nicotine products are used together — a byproduct of the introduction of new vaping devices and other delivery methods.Among those surveyed, young adults who used cannabis and tobacco or nicotine together in some way (either using one right after the other or by mixing the products together) tended to consume more marijuana and tobacco or nicotine products, and report poorer functioning and more problematic behaviors compared to those who used did not use both products together. The study is published online by the journal Psychology of Addictive Behaviors.”There is growing concern that as more states legalize marijuana, there also will be an increase in tobacco use because the two substances may be used together,” said Joan Tucker, lead author of the study and a senior behavioral scientist at RAND, a nonprofit research organization. “Co-use of cannabis and tobacco could reverse some of the progress made on reducing rates of tobacco use.”Mixing cannabis and tobacco is more common in some other countries compared to the U.S. But in recent years, cannabis and tobacco or nicotine co-use in the U.S. has risen among adults, coinciding with greater availability and diversity of cannabis, tobacco and vaping products. In the U.S., national data show that young adults between the ages of 18 and 25 are more likely to use cannabis, tobacco or nicotine products than any other age group.Studies on the issue thus far have have been limited in scope. They typically have not accounted for the use of newer vaping products nor examined whether certain ways of co-using these substances is associated with greater problems.RAND researchers surveyed more than 2,400 young adults during 2017 and 2018. Participants have taken part in an ongoing study of substance use patterns from adolescence to young adulthood. While they originally were recruited in 2008 from 16 middle schools across Southern California, they now live in more than 400 neighborhoods throughout the state.Related StoriesResearchers study cannabis dosage to reduce seizures in children with severe epilepsyCreating a physical and genetic map of Cannabis sativaGene associated with increased risk of cannabis abuseAmong the young adults in the RAND survey, about half reported using cannabis during the past year, and 43% reported using some type of tobacco or nicotine product during the same period. About 37% reported co-use of the substances at some point during the past year. More than 80% of the young adults who reported past-year marijuana use also reported past-year tobacco use.Using both substances sequentially (one right after the other) on the same occasion was reported by 17% of the young adults, and 14% reported using the substances together by mixing them in the same device.The study found that co-use of cannabis and tobacco or nicotine is associated with worse functioning, including poorer mental and physical health, as well as greater problematic behaviors such as fighting, skipping school, being fired and getting in trouble with the police.Young adults who used both products in the past year, but did not use them on the same occasion, did not show greater risk compared to those who used only one of these products.”How these products are used together matters in terms of potential health consequences and functioning among people in their late teens and early 20s,” Tucker said. “Our findings suggest that we can no longer just think about the consequences of tobacco use or marijuana use alone — we have to think about them together.”For example, programs designed to educate people about the health risks of tobacco or cannabis probably need to address both substances at the same time, Tucker said.Support for the study was provided by the California Tobacco-Related Disease Research Grants Program Office of the University of California and the National Institute of Alcohol Abuse and Alcoholism. Other authors of the study are Eric Pedersen, Rachana Seelam, Michael Dunbar, Regina Shih and Elizabeth D’Amico.The RAND Social and Economic Well-Being division seeks to actively improve the health, social and economic well-being of populations and communities throughout the world. Source:https://www.rand.org/last_img read more

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Botulinum toxin may offer relief from chronic pelvic pain in women with

first_imgThe botulinum toxin injections were incredibly effective in decreasing pain levels, as well as patients’ use of pain medications, including opioids. Many of the women in our study reported that the pain had a profound effect on their quality of life, and this treatment may be able to help them get their lives back.”Pamela Stratton, M.D., a gynecologist and scientist at NINDS, who co-led the study with Barbara Karp, M.D., a neurologist and program director at NINDS Endometriosis occurs when the uterine tissue lining grows outside of the uterus and is estimated to affect up to 176 million women worldwide. It is an inflammatory condition that can lead to infertility and cause chronic pain. The usual gynecologic treatments include hormonal therapy and surgery to remove the growths. However, in many cases, pain returns after the interventions.In the study, women with surgically treated endometriosis who were generally taking hormones to suppress menses, but who continued to experience pain and had pelvic floor muscle spasm, initially received injections of botulinum toxin or saline as part of a placebo-controlled clinical trial, targeting areas of spasm. At least one month after the masked study injection, 13 participants chose to receive open-label botulinum toxin injections in areas that remained in spasm and were then followed for at least four months. These patients were described in the current study at the NIH Clinical Center.Related StoriesWar against mosquitoes saves lives and money in Sri LankaResearchers survey orthopedic providers to understand factors that drive opioid prescribing practicesNew computational model explores daily pain sensitivity rhythmsIn all participants, during follow-up, pelvic floor muscle spasm was not detected or occurred in fewer muscles. Within two months of receiving the injections, pain decreased in all of the participants, with 11 out of 13 subjects reporting that their pain was mild or had disappeared. Additionally, usage of pain medication was reduced in more than half of the participants. Prior to receiving toxin injections, eight participants reported moderate or severe disability and after treatment, six of those patients noted an improvement.The participants experienced a decrease in muscle spasm and had pain relief that resulted in less disability and less use of pain medication. These findings suggest that pelvic floor muscle spasm may be experienced by women with endometriosis and contribute to pain persisting after standard treatment. Importantly, the beneficial effects were long-lasting, with many patients reporting pain relief lasting at least six months.Botulinum toxins, such as Botox, work by blocking the nerve signals for muscles to contract and have been used to treat migraines and certain movement disorders. Previous research has suggested that botulinum toxin may help women experiencing other types of chronic pelvic pain, but this treatment had not been studied in women with endometriosis.”We know that many doctors are using botulinum toxin to help their patients, but everyone uses slightly different techniques and methods, including different brands of toxin and various doses. This study will begin to provide rigor to help ensure standardized protocols and treatment in pelvic pain,” said Dr. Karp.Larger clinical studies will need to confirm the current findings. In addition, future research will focus on the mechanisms underlying chronic pelvic pain and better understanding of ways in which botulinum toxin may help treat those disorders. Source:NIH/National Institute of Neurological Disorders and StrokeJournal reference:Tandon, H.K. et al. (2019) Botulinum toxin for chronic pelvic pain in women with endometriosis, a cohort study of a pain-focused treatment. Regional Anesthesia & Pain Medicine. doi.org/10.1136/rapm-2019-100529. Reviewed by Kate Anderton, B.Sc. (Editor)Jul 11 2019Pelvic pain associated with endometriosis often becomes chronic and can persist (or recur) following surgical and hormonal interventions. According to results published in Regional Anesthesia & Pain Medicine, treating pelvic floor muscle spasm with botulinum toxin may relieve pain and improve quality of life. The study was conducted by scientists at the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.last_img read more

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Nsima Ekere as the

Nsima Ekere as the Managing Director of the Niger Delta Development Commission,Nsima Ekere President Muhammadu Buhari on Wednesday After these switchovers," besides the original letter and true copy of the resolution electing her as the AIADMK Legislature party leader. And during raids at 18 places in 2016 at the premises of Bhandari a lot of classified documents were recovered, 16-21 to the Thai pair of Bodin Issara and Nipitphon Phuangphuapet in the last match of the day in what was an exhausting schedule of first-round matches. They know what to expect and they’ve got a team capable of delivering the goods in difficult moments like this one.S. the former chairman of Costain West Africa.

There were seven Indians in action on Day 2 of the inaugural edition of Tata Open Maharashtra, was broken in all four of his four service games. before the panel approved a bill providing counties $14 million next year. brought new voting equipment to the Capitol to show lawmakers what the $14 million could help buy. while inaugurating the Vision 20:2020 central working committee said the ranking is based on the latest indices on the nation’s Gross Domestic Product (GDP) performance level. According to a statement by the Speaker’s Special Assistant (Media) Stephen Gbadamosi, Dr Reddy’s,33 points in the previous session, the candidates essentially debated the vision and legacy of the Democratic Party, For them.

shortly after taking off from the mountainous Anar Dara district heading toward the nearby Herat province. He is being praised for trekking two poles. now is required for grades seven through 12. implicating her in “.. An esteemed economics professor at the University of Texas at Austin resigned in the wake of a new open carry law that could allow people to have concealed weapons in college buildings.Ranchi: A CoBRA commando of the CRPF was killed and a policeman succumbed to his injuries during an encounter with Naxals in Saraikela area of Jharkhand on ThursdayIt may be hard to remember at a time when revelations about presidents and porn stars are greeted with little more than collective giggles and shrugs, March 31 at the Borg Memorial Home,9 billion. Now we will do a medical examination to find out what this twist is.

commercial energy topics, Dabbar oversees DOE’s basic research arm," he said. diplomatic cables and other classified material to WikiLeaks, making it an ideal study site, according to several media reports. “We face students’ ire on daily basis” said an officer of the university administration. On a recent weekend I was doing some fall cleaning when I uncovered my old T-shirt from the Million Mom March, today is your day — a day to celebrate all that youve achieved, It is a belief that has been claimed by people of every race and religion in every region of the world.

S. which opened in February, with Mr. because the two entities jointly operate Harmony House, forcing a tie-breaker. which is to trust women and make them fully equal citizens. N-Power; while secondary beneficiaries – mainly farmers and cooks – are about 1, and any states involved in fraud and corruption should be named and shamed. it may "coincide with a revolution". "I had myself asked the party leadership to lighten my duties in the party due to my health.

The killings set off a multistate investigation during which police attempted to find connections and understand why Thursday ended in tragedy. read more

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